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BDBM340061 2-{5-Fluoro-1-[2-(morpholin-4-yl)ethyl]-1H-indazol-3-yl}-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid::US9758517, Example 21

SMILES: OC(=O)c1ccnc2cc([nH]c12)-c1nn(CCN2CCOCC2)c2ccc(F)cc12

InChI Key: InChIKey=DYFQVMZDYDVEKS-UHFFFAOYSA-N

Data: 1 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340061   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340061
PNG
(2-{5-Fluoro-1-[2-(morpholin-4-yl)ethyl]-1H-indazol...)
Show SMILES OC(=O)c1ccnc2cc([nH]c12)-c1nn(CCN2CCOCC2)c2ccc(F)cc12
Show InChI InChI=1S/C21H20FN5O3/c22-13-1-2-18-15(11-13)20(25-27(18)6-5-26-7-9-30-10-8-26)17-12-16-19(24-17)14(21(28)29)3-4-23-16/h1-4,11-12,24H,5-10H2,(H,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair