BindingDB logo
myBDB logout

BDBM340084 US9758524, Example 11

SMILES: CCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)\C=C\COC)n3ccnc(N)c23)c1

InChI Key: InChIKey=LNWUGMPAEUGTGI-HVPBSWBLSA-N

Data: 5 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 340084   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM340084
PNG
(US9758524, Example 11)
Show SMILES CCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)\C=C\COC)n3ccnc(N)c23)c1
Show InChI InChI=1S/C29H31N7O3/c1-3-19-12-13-31-23(18-19)33-29(38)21-10-8-20(9-11-21)25-26-27(30)32-14-16-36(26)28(34-25)22-6-4-15-35(22)24(37)7-5-17-39-2/h5,7-14,16,18,22H,3-4,6,15,17H2,1-2H3,(H2,30,32)(H,31,33,38)/b7-5+/t22-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 505n/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Btk enzyme (His-Btk (Millipore catalog #14-552), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM D...


US Patent US9758524 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM340084
PNG
(US9758524, Example 11)
Show SMILES CCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)\C=C\COC)n3ccnc(N)c23)c1
Show InChI InChI=1S/C29H31N7O3/c1-3-19-12-13-31-23(18-19)33-29(38)21-10-8-20(9-11-21)25-26-27(30)32-14-16-36(26)28(34-25)22-6-4-15-35(22)24(37)7-5-17-39-2/h5,7-14,16,18,22H,3-4,6,15,17H2,1-2H3,(H2,30,32)(H,31,33,38)/b7-5+/t22-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+3n/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...


US Patent US9758524 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM340084
PNG
(US9758524, Example 11)
Show SMILES CCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)\C=C\COC)n3ccnc(N)c23)c1
Show InChI InChI=1S/C29H31N7O3/c1-3-19-12-13-31-23(18-19)33-29(38)21-10-8-20(9-11-21)25-26-27(30)32-14-16-36(26)28(34-25)22-6-4-15-35(22)24(37)7-5-17-39-2/h5,7-14,16,18,22H,3-4,6,15,17H2,1-2H3,(H2,30,32)(H,31,33,38)/b7-5+/t22-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+3n/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Lyn enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lyn enzyme (M...


US Patent US9758524 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM340084
PNG
(US9758524, Example 11)
Show SMILES CCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)\C=C\COC)n3ccnc(N)c23)c1
Show InChI InChI=1S/C29H31N7O3/c1-3-19-12-13-31-23(18-19)33-29(38)21-10-8-20(9-11-21)25-26-27(30)32-14-16-36(26)28(34-25)22-6-4-15-35(22)24(37)7-5-17-39-2/h5,7-14,16,18,22H,3-4,6,15,17H2,1-2H3,(H2,30,32)(H,31,33,38)/b7-5+/t22-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+3n/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
FynT enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.FynT enzyme ...


US Patent US9758524 (2017)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM340084
PNG
(US9758524, Example 11)
Show SMILES CCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)\C=C\COC)n3ccnc(N)c23)c1
Show InChI InChI=1S/C29H31N7O3/c1-3-19-12-13-31-23(18-19)33-29(38)21-10-8-20(9-11-21)25-26-27(30)32-14-16-36(26)28(34-25)22-6-4-15-35(22)24(37)7-5-17-39-2/h5,7-14,16,18,22H,3-4,6,15,17H2,1-2H3,(H2,30,32)(H,31,33,38)/b7-5+/t22-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+3n/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Src enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Src enzyme (M...


US Patent US9758524 (2017)

More data for this
Ligand-Target Pair