BDBM340125 US10934296, Example 13::US9758524, Example 13

SMILES Nc1nccn2c(nc(-c3ccc(C(=O)Nc4ccccn4)c(F)c3)c12)[C@@H]1CCCN1C(=O)C=C

InChI Key InChIKey=JVLFCLUJKGWBNX-SFHVURJKSA-N

Data  10 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 340125   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340125(US10934296, Example 13 | US9758524, Example 13)
Affinity DataEC50: <10nMAssay Description:Btk enzyme (His-Btk (Millipore catalog #14-552), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340125(US10934296, Example 13 | US9758524, Example 13)
Affinity DataEC50: >1.00E+3nMAssay Description:Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340125(US10934296, Example 13 | US9758524, Example 13)
Affinity DataEC50: >1.00E+3nMAssay Description:Src enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Src enzyme (M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340125(US10934296, Example 13 | US9758524, Example 13)
Affinity DataEC50: >1.00E+3nMAssay Description:FynT enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.FynT enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340125(US10934296, Example 13 | US9758524, Example 13)
Affinity DataEC50: >1.00E+3nMAssay Description:Src enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Src enzyme (M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340125(US10934296, Example 13 | US9758524, Example 13)
Affinity DataEC50: >1.00E+3nMAssay Description:FynT enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.FynT enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340125(US10934296, Example 13 | US9758524, Example 13)
Affinity DataEC50: >1.00E+3nMAssay Description:Lyn enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lyn enzyme (M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340125(US10934296, Example 13 | US9758524, Example 13)
Affinity DataEC50: <10nMAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Btk enzyme (H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340125(US10934296, Example 13 | US9758524, Example 13)
Affinity DataEC50: >1.00E+3nMAssay Description:Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340125(US10934296, Example 13 | US9758524, Example 13)
Affinity DataEC50: >1.00E+3nMAssay Description:Lyn enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lyn enzyme (M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent