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BDBM340143 US9758524, Example 32

SMILES: CC(C)(O)C#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12

InChI Key: InChIKey=CLYKFKHFOVJYRG-FQEVSTJZSA-N

Data: 5 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 340143   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM340143
PNG
(US9758524, Example 32)
Show SMILES CC(C)(O)C#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C28H27N7O3/c1-28(2,38)13-12-22(36)34-16-5-6-20(34)26-33-23(24-25(29)31-15-17-35(24)26)18-8-10-19(11-9-18)27(37)32-21-7-3-4-14-30-21/h3-4,7-11,14-15,17,20,38H,5-6,16H2,1-2H3,(H2,29,31)(H,30,32,37)/t20-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<10n/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Btk enzyme (His-Btk (Millipore catalog #14-552), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM D...


US Patent US9758524 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM340143
PNG
(US9758524, Example 32)
Show SMILES CC(C)(O)C#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C28H27N7O3/c1-28(2,38)13-12-22(36)34-16-5-6-20(34)26-33-23(24-25(29)31-15-17-35(24)26)18-8-10-19(11-9-18)27(37)32-21-7-3-4-14-30-21/h3-4,7-11,14-15,17,20,38H,5-6,16H2,1-2H3,(H2,29,31)(H,30,32,37)/t20-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+3n/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...


US Patent US9758524 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM340143
PNG
(US9758524, Example 32)
Show SMILES CC(C)(O)C#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C28H27N7O3/c1-28(2,38)13-12-22(36)34-16-5-6-20(34)26-33-23(24-25(29)31-15-17-35(24)26)18-8-10-19(11-9-18)27(37)32-21-7-3-4-14-30-21/h3-4,7-11,14-15,17,20,38H,5-6,16H2,1-2H3,(H2,29,31)(H,30,32,37)/t20-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+3n/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Lyn enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lyn enzyme (M...


US Patent US9758524 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM340143
PNG
(US9758524, Example 32)
Show SMILES CC(C)(O)C#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C28H27N7O3/c1-28(2,38)13-12-22(36)34-16-5-6-20(34)26-33-23(24-25(29)31-15-17-35(24)26)18-8-10-19(11-9-18)27(37)32-21-7-3-4-14-30-21/h3-4,7-11,14-15,17,20,38H,5-6,16H2,1-2H3,(H2,29,31)(H,30,32,37)/t20-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+3n/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
FynT enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.FynT enzyme ...


US Patent US9758524 (2017)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM340143
PNG
(US9758524, Example 32)
Show SMILES CC(C)(O)C#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C28H27N7O3/c1-28(2,38)13-12-22(36)34-16-5-6-20(34)26-33-23(24-25(29)31-15-17-35(24)26)18-8-10-19(11-9-18)27(37)32-21-7-3-4-14-30-21/h3-4,7-11,14-15,17,20,38H,5-6,16H2,1-2H3,(H2,29,31)(H,30,32,37)/t20-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+3n/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Src enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Src enzyme (M...


US Patent US9758524 (2017)

More data for this
Ligand-Target Pair