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BDBM340150 US9758524, Example 39

SMILES: CC#CC(=O)N(C)[C@@H](C)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12

InChI Key: InChIKey=JPBICDXNXNVFOA-HNNXBMFYSA-N

Data: 5 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 340150   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM340150
PNG
(US9758524, Example 39)
Show SMILES CC#CC(=O)N(C)[C@@H](C)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12
Show InChI InChI=1S/C26H22F3N7O2/c1-4-5-20(37)35(3)15(2)24-34-21(22-23(30)32-12-13-36(22)24)16-6-8-17(9-7-16)25(38)33-19-14-18(10-11-31-19)26(27,28)29/h6-15H,1-3H3,(H2,30,32)(H,31,33,38)/t15-/m0/s1
PDB
MMDB

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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
UniChem
US Patent
n/an/an/an/a<10n/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Btk enzyme (His-Btk (Millipore catalog #14-552), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM D...


US Patent US9758524 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM340150
PNG
(US9758524, Example 39)
Show SMILES CC#CC(=O)N(C)[C@@H](C)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12
Show InChI InChI=1S/C26H22F3N7O2/c1-4-5-20(37)35(3)15(2)24-34-21(22-23(30)32-12-13-36(22)24)16-6-8-17(9-7-16)25(38)33-19-14-18(10-11-31-19)26(27,28)29/h6-15H,1-3H3,(H2,30,32)(H,31,33,38)/t15-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/an/an/a>1.00E+3n/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...


US Patent US9758524 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM340150
PNG
(US9758524, Example 39)
Show SMILES CC#CC(=O)N(C)[C@@H](C)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12
Show InChI InChI=1S/C26H22F3N7O2/c1-4-5-20(37)35(3)15(2)24-34-21(22-23(30)32-12-13-36(22)24)16-6-8-17(9-7-16)25(38)33-19-14-18(10-11-31-19)26(27,28)29/h6-15H,1-3H3,(H2,30,32)(H,31,33,38)/t15-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

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DrugBank
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UniChem
US Patent
n/an/an/an/a>1.00E+3n/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Lyn enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lyn enzyme (M...


US Patent US9758524 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM340150
PNG
(US9758524, Example 39)
Show SMILES CC#CC(=O)N(C)[C@@H](C)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12
Show InChI InChI=1S/C26H22F3N7O2/c1-4-5-20(37)35(3)15(2)24-34-21(22-23(30)32-12-13-36(22)24)16-6-8-17(9-7-16)25(38)33-19-14-18(10-11-31-19)26(27,28)29/h6-15H,1-3H3,(H2,30,32)(H,31,33,38)/t15-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/an/an/a>1.00E+3n/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
FynT enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.FynT enzyme ...


US Patent US9758524 (2017)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM340150
PNG
(US9758524, Example 39)
Show SMILES CC#CC(=O)N(C)[C@@H](C)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12
Show InChI InChI=1S/C26H22F3N7O2/c1-4-5-20(37)35(3)15(2)24-34-21(22-23(30)32-12-13-36(22)24)16-6-8-17(9-7-16)25(38)33-19-14-18(10-11-31-19)26(27,28)29/h6-15H,1-3H3,(H2,30,32)(H,31,33,38)/t15-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
UniChem
US Patent
n/an/an/an/a>1.00E+3n/an/an/an/a



Merck Sharp & Dohme B.V.

US Patent


Assay Description
Src enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Src enzyme (M...


US Patent US9758524 (2017)

More data for this
Ligand-Target Pair