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BDBM340201 (2S,4S)-N2-(1-acetyl- 1H-indol-3-yl)-N1-(3- chloro-2-fluorobenzyl)- 4-fluoropyrrolidine-1,2- dicarboxamide::US9758537, Compound 4

SMILES: CC(=O)n1cc(NC(=O)[C@@H]2C[C@H](F)CN2C(=O)NCc2cccc(Cl)c2F)c2ccccc12

InChI Key: InChIKey=NXNVBVMBGQLNHW-YWZLYKJASA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340201   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Factor D


(Homo sapiens (Human))
BDBM340201
PNG
((2S,4S)-N2-(1-acetyl- 1H-indol-3-yl)-N1-(3- chloro...)
Show SMILES CC(=O)n1cc(NC(=O)[C@@H]2C[C@H](F)CN2C(=O)NCc2cccc(Cl)c2F)c2ccccc12
Show InChI InChI=1S/C23H21ClF2N4O3/c1-13(31)29-12-18(16-6-2-3-8-19(16)29)28-22(32)20-9-15(25)11-30(20)23(33)27-10-14-5-4-7-17(24)21(14)26/h2-8,12,15,20H,9-11H2,1H3,(H,27,33)(H,28,32)/t15-,20-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



Achillion Pharmaceuticals

US Patent


Assay Description
Human factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce...


US Patent US9758537 (2017)

More data for this
Ligand-Target Pair