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BDBM340212 2-(3-acetyl-1H-indol-1- yl)-1-((2S,4R)-2-(5- chloro-1H- benzo[d]imidazol-2-yl)- 4-fluoropyrrolidin-1- yl)ethanone::US9758537, Compound 15

SMILES: CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2c2nc3cc(Cl)ccc3[nH]2)c2ccccc12

InChI Key: InChIKey=QZOAWKSHMBBVOU-VFNWGFHPSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340212   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Factor D


(Homo sapiens (Human))
BDBM340212
PNG
(2-(3-acetyl-1H-indol-1- yl)-1-((2S,4R)-2-(5- chlor...)
Show SMILES CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2c2nc3cc(Cl)ccc3[nH]2)c2ccccc12
Show InChI InChI=1S/C23H20ClFN4O2/c1-13(30)17-11-28(20-5-3-2-4-16(17)20)12-22(31)29-10-15(25)9-21(29)23-26-18-7-6-14(24)8-19(18)27-23/h2-8,11,15,21H,9-10,12H2,1H3,(H,26,27)/t15-,21+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



Achillion Pharmaceuticals

US Patent


Assay Description
Human factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce...


US Patent US9758537 (2017)

More data for this
Ligand-Target Pair