BindingDB logo
myBDB logout

BDBM340230 2-(3-acetyl-1H-indol-1- yl)-1-((2S,4R)-4-fluoro- 2-(isoindoline-2- carbonyl)pyrrolidin-1- yl)ethanone::US9758537, Compound 33

SMILES: CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N2Cc3ccccc3C2)c2ccccc12

InChI Key: InChIKey=ZBEQMAWWMORWTB-XXBNENTESA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340230   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Factor D


(Homo sapiens (Human))
BDBM340230
PNG
(2-(3-acetyl-1H-indol-1- yl)-1-((2S,4R)-4-fluoro- 2...)
Show SMILES CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N2Cc3ccccc3C2)c2ccccc12
Show InChI InChI=1S/C25H24FN3O3/c1-16(30)21-14-27(22-9-5-4-8-20(21)22)15-24(31)29-13-19(26)10-23(29)25(32)28-11-17-6-2-3-7-18(17)12-28/h2-9,14,19,23H,10-13,15H2,1H3/t19-,23+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



Achillion Pharmaceuticals

US Patent


Assay Description
Human factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce...


US Patent US9758537 (2017)

More data for this
Ligand-Target Pair