BindingDB logo
myBDB logout

BDBM340231 (2S,4R)-1-(2-(3-acetyl- 1H-indol-1-yl)acetyl)- N-(3-chloro-2- fluorobenzyl)-4-fluoro- N-methylpyrrolidine-2- carboxamide::US9758537, Compound 34

SMILES: CN(Cc1cccc(Cl)c1F)C(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cc(C(C)=O)c2ccccc12

InChI Key: InChIKey=MPZWENNXDSXCQL-VGSWGCGISA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340231   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Factor D


(Homo sapiens (Human))
BDBM340231
PNG
((2S,4R)-1-(2-(3-acetyl- 1H-indol-1-yl)acetyl)- N-(...)
Show SMILES CN(Cc1cccc(Cl)c1F)C(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cc(C(C)=O)c2ccccc12
Show InChI InChI=1S/C25H24ClF2N3O3/c1-15(32)19-13-30(21-9-4-3-7-18(19)21)14-23(33)31-12-17(27)10-22(31)25(34)29(2)11-16-6-5-8-20(26)24(16)28/h3-9,13,17,22H,10-12,14H2,1-2H3/t17-,22+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



Achillion Pharmaceuticals

US Patent


Assay Description
Human factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce...


US Patent US9758537 (2017)

More data for this
Ligand-Target Pair