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BDBM340233 (2S,4R)-N-(3-chloro-2- fluorobenzyl)-1-(2-(3- cyano-1H-indol-1- yl)acetyl)-4- fluoropyrrolidine-2- carboxamide::US9758537, Compound 36

SMILES: F[C@@H]1C[C@H](N(C1)C(=O)Cn1cc(C#N)c2ccccc12)C(=O)NCc1cccc(Cl)c1F

InChI Key: InChIKey=FSRFQRAUZNASQB-UZLBHIALSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340233   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Factor D


(Homo sapiens (Human))
BDBM340233
PNG
((2S,4R)-N-(3-chloro-2- fluorobenzyl)-1-(2-(3- cyan...)
Show SMILES F[C@@H]1C[C@H](N(C1)C(=O)Cn1cc(C#N)c2ccccc12)C(=O)NCc1cccc(Cl)c1F
Show InChI InChI=1S/C23H19ClF2N4O2/c24-18-6-3-4-14(22(18)26)10-28-23(32)20-8-16(25)12-30(20)21(31)13-29-11-15(9-27)17-5-1-2-7-19(17)29/h1-7,11,16,20H,8,10,12-13H2,(H,28,32)/t16-,20+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Achillion Pharmaceuticals

US Patent


Assay Description
Human factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce...


US Patent US9758537 (2017)

More data for this
Ligand-Target Pair