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BDBM340262 (2S,4R)-N-(3-chloro-2- fluorobenzyl)-1-(2-(1,1- dioxido-4H- benzo[e][1,2,4]thiadiazin- 4-yl)acetyl)-4- fluoropyrrolidine-2- carboxamide::US9758537, Compound 65

SMILES: F[C@@H]1C[C@H](N(C1)C(=O)CN1C=NS(=O)(=O)c2ccccc12)C(=O)NCc1cccc(Cl)c1F

InChI Key: InChIKey=ZIAACBQZUAKWQO-PBHICJAKSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340262   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Factor D


(Homo sapiens (Human))
BDBM340262
PNG
((2S,4R)-N-(3-chloro-2- fluorobenzyl)-1-(2-(1,1- di...)
Show SMILES F[C@@H]1C[C@H](N(C1)C(=O)CN1C=NS(=O)(=O)c2ccccc12)C(=O)NCc1cccc(Cl)c1F
Show InChI InChI=1S/C21H19ClF2N4O4S/c22-15-5-3-4-13(20(15)24)9-25-21(30)17-8-14(23)10-28(17)19(29)11-27-12-26-33(31,32)18-7-2-1-6-16(18)27/h1-7,12,14,17H,8-11H2,(H,25,30)/t14-,17+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



Achillion Pharmaceuticals

US Patent


Assay Description
Human factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce...


US Patent US9758537 (2017)

More data for this
Ligand-Target Pair