BindingDB logo
myBDB logout

BDBM340265 (2S,4R)-N-(3-chloro-2- fluorobenzyl)-1-(2-(3,4- dihydro-1H-pyrido[3,4- b]indol-9(2H)- yl)acetyl)-4- fluoropyrrolidine-2- carboxamide::US9758537, Compound 68

SMILES: F[C@@H]1C[C@H](N(C1)C(=O)Cn1c2CNCCc2c2ccccc12)C(=O)NCc1cccc(Cl)c1F

InChI Key: InChIKey=TXZVUADUPBFBCX-IERDGZPVSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340265   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Factor D


(Homo sapiens (Human))
BDBM340265
PNG
((2S,4R)-N-(3-chloro-2- fluorobenzyl)-1-(2-(3,4- di...)
Show SMILES F[C@@H]1C[C@H](N(C1)C(=O)Cn1c2CNCCc2c2ccccc12)C(=O)NCc1cccc(Cl)c1F
Show InChI InChI=1S/C25H25ClF2N4O2/c26-19-6-3-4-15(24(19)28)11-30-25(34)21-10-16(27)13-32(21)23(33)14-31-20-7-2-1-5-17(20)18-8-9-29-12-22(18)31/h1-7,16,21,29H,8-14H2,(H,30,34)/t16-,21+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



Achillion Pharmaceuticals

US Patent


Assay Description
Human factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce...


US Patent US9758537 (2017)

More data for this
Ligand-Target Pair