BindingDB logo
myBDB logout

BDBM340294 1-(2-((2S,4R)-2-(2'- chloro-2- fluorobiphenyl-3- ylcarbamoyl)-4- fluoropyrrolidin-1-yl)- 2-oxoethyl)-4,5,6,7- tetrahydro-1H-indazole- 3-carboxamide::US9758537, Compound 104

SMILES: NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c2CCCCc12

InChI Key: InChIKey=WXLHJULZBZPLKU-QRQCRPRQSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340294   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Factor D


(Homo sapiens (Human))
BDBM340294
PNG
(1-(2-((2S,4R)-2-(2'- chloro-2- fluorobiphenyl-3- y...)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c2CCCCc12
Show InChI InChI=1S/C27H26ClF2N5O3/c28-19-9-3-1-6-16(19)17-8-5-10-20(24(17)30)32-27(38)22-12-15(29)13-34(22)23(36)14-35-21-11-4-2-7-18(21)25(33-35)26(31)37/h1,3,5-6,8-10,15,22H,2,4,7,11-14H2,(H2,31,37)(H,32,38)/t15-,22+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Achillion Pharmaceuticals

US Patent


Assay Description
Human factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce...


US Patent US9758537 (2017)


Article DOI: 10.1021/jm0303857
BindingDB Entry DOI: 10.7270/Q2C53NZ9
More data for this
Ligand-Target Pair