BDBM340337 US9758538, Example 25::US9758538, Example 26::US9758538, Example 27

SMILES CN(c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1)C1(CO)CCN(C1)C(=O)OC(C)(C)C

InChI Key InChIKey=WMHKZFVZNCNESN-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 340337   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM340337(US9758538, Example 25 | US9758538, Example 26 | US...)
Affinity DataKi: <0.0180nMAssay Description:The biochemical assays of kinase activity of full-length PI3Kα (full-length p110α/p85α) or truncated PI3Kα (p110α/iSH2 p85&#...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM340337(US9758538, Example 25 | US9758538, Example 26 | US...)
Affinity DataKi:  0.0490nMAssay Description:The biochemical assays of kinase activity of full-length PI3Kα (full-length p110α/p85α) or truncated PI3Kα (p110α/iSH2 p85&#...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM340337(US9758538, Example 25 | US9758538, Example 26 | US...)
Affinity DataKi:  0.717nMAssay Description:The biochemical assays of kinase activity of full-length PI3Kα (full-length p110α/p85α) or truncated PI3Kα (p110α/iSH2 p85&#...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent