BindingDB logo
myBDB logout

BDBM340355 US9758538, Example 43

SMILES: Nc1ncc(cn1)-c1cc(NC2(CO)CNC2)nc(n1)N1CCOCC1

InChI Key: InChIKey=VABASLNNTBVODF-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340355   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM340355
PNG
(US9758538, Example 43)
Show SMILES Nc1ncc(cn1)-c1cc(NC2(CO)CNC2)nc(n1)N1CCOCC1
Show InChI InChI=1S/C16H22N8O2/c17-14-19-6-11(7-20-14)12-5-13(23-16(10-25)8-18-9-16)22-15(21-12)24-1-3-26-4-2-24/h5-7,18,25H,1-4,8-10H2,(H2,17,19,20)(H,21,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.97n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
The biochemical assays of kinase activity of full-length PI3Kα (full-length p110α/p85α) or truncated PI3Kα (p110α/iSH2 p85&#...


US Patent US9758538 (2017)

More data for this
Ligand-Target Pair