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BDBM340386 US9758538, Example 74

SMILES: Nc1ncc(cn1)-c1cc(N[C@@]2(CO)CCN(C2)C(=O)[C@H]2C[C@@H]2F)nc(n1)N1CCOCC1

InChI Key: InChIKey=YZZOZAHUNZGFOL-GXZWQRSESA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340386   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM340386
PNG
(US9758538, Example 74)
Show SMILES Nc1ncc(cn1)-c1cc(N[C@@]2(CO)CCN(C2)C(=O)[C@H]2C[C@@H]2F)nc(n1)N1CCOCC1
Show InChI InChI=1S/C21H27FN8O3/c22-15-7-14(15)18(32)30-2-1-21(11-30,12-31)28-17-8-16(13-9-24-19(23)25-10-13)26-20(27-17)29-3-5-33-6-4-29/h8-10,14-15,31H,1-7,11-12H2,(H2,23,24,25)(H,26,27,28)/t14-,15-,21-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.153n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
The biochemical assays of kinase activity of full-length PI3Kα (full-length p110α/p85α) or truncated PI3Kα (p110α/iSH2 p85&#...


US Patent US9758538 (2017)

More data for this
Ligand-Target Pair