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BDBM340427 US9758538, Example 115

SMILES: Nc1ncc(cn1)-c1nc(nc(N[C@@]2(CO)CCN(C2)C(=O)C2(F)CCC2)c1F)N1CCOCC1

InChI Key: InChIKey=TVQUTOHQNKTWFE-NRFANRHFSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340427   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM340427
PNG
(US9758538, Example 115)
Show SMILES Nc1ncc(cn1)-c1nc(nc(N[C@@]2(CO)CCN(C2)C(=O)C2(F)CCC2)c1F)N1CCOCC1
Show InChI InChI=1S/C22H28F2N8O3/c23-15-16(14-10-26-19(25)27-11-14)28-20(31-6-8-35-9-7-31)29-17(15)30-21(13-33)4-5-32(12-21)18(34)22(24)2-1-3-22/h10-11,33H,1-9,12-13H2,(H2,25,26,27)(H,28,29,30)/t21-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.0360n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
The biochemical assays of kinase activity of full-length PI3Kα (full-length p110α/p85α) or truncated PI3Kα (p110α/iSH2 p85&#...


US Patent US9758538 (2017)

More data for this
Ligand-Target Pair