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BDBM340438 US9758538, Example 127

SMILES: Cc1ncc(cc1F)-c1cc(N[C@@]2(CO)CCN(C2)C(=O)OC(C)(C)C)nc(n1)N1CCOCC1

InChI Key: InChIKey=QJZJOEBVXDWOQG-DEOSSOPVSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340438   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM340438
PNG
(US9758538, Example 127)
Show SMILES Cc1ncc(cc1F)-c1cc(N[C@@]2(CO)CCN(C2)C(=O)OC(C)(C)C)nc(n1)N1CCOCC1
Show InChI InChI=1S/C24H33FN6O4/c1-16-18(25)11-17(13-26-16)19-12-20(28-21(27-19)30-7-9-34-10-8-30)29-24(15-32)5-6-31(14-24)22(33)35-23(2,3)4/h11-13,32H,5-10,14-15H2,1-4H3,(H,27,28,29)/t24-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
19n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
The biochemical assays of kinase activity of full-length PI3Kα (full-length p110α/p85α) or truncated PI3Kα (p110α/iSH2 p85&#...


US Patent US9758538 (2017)

More data for this
Ligand-Target Pair