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BDBM340455 US9758538, Example 145

SMILES: Nc1ncc(cn1)-c1nc(nc(N[C@@]2(CO)CCCNC2)c1F)N1CCOCC1

InChI Key: InChIKey=DVYRWBIURYYWSH-SFHVURJKSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340455   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM340455
PNG
(US9758538, Example 145)
Show SMILES Nc1ncc(cn1)-c1nc(nc(N[C@@]2(CO)CCCNC2)c1F)N1CCOCC1
Show InChI InChI=1S/C18H25FN8O2/c19-13-14(12-8-22-16(20)23-9-12)24-17(27-4-6-29-7-5-27)25-15(13)26-18(11-28)2-1-3-21-10-18/h8-9,21,28H,1-7,10-11H2,(H2,20,22,23)(H,24,25,26)/t18-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
2.53n/an/an/an/an/an/an/an/a



PFIZER INC.

US Patent


Assay Description
The biochemical assays of kinase activity of full-length PI3Kα (full-length p110α/p85α) or truncated PI3Kα (p110α/iSH2 p85&#...


US Patent US9758538 (2017)

More data for this
Ligand-Target Pair