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BDBM340785 1-(4-Propoxy-2′-(1H-tetrazol-5-yl)-5-(4,4,4-trifluorobutyl)-[1,1′-biphenyl]-3-yl)-3-(p-tolyl)urea::US9765018, Example 31

SMILES: CCCOc1c(CCCC(F)(F)F)cc(cc1NC(=O)Nc1ccc(C)cc1)-c1ccccc1-c1nnn[nH]1

InChI Key: InChIKey=UANQLBPEIQDJCQ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340785   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM340785
PNG
(1-(4-Propoxy-2′-(1H-tetrazol-5-yl)-5-(4,4,4-...)
Show SMILES CCCOc1c(CCCC(F)(F)F)cc(cc1NC(=O)Nc1ccc(C)cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C28H29F3N6O2/c1-3-15-39-25-19(7-6-14-28(29,30)31)16-20(22-8-4-5-9-23(22)26-34-36-37-35-26)17-24(25)33-27(38)32-21-12-10-18(2)11-13-21/h4-5,8-13,16-17H,3,6-7,14-15H2,1-2H3,(H2,32,33,38)(H,34,35,36,37)
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PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Syngene International Limited; Bristol-Myers Squibb Company

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...


US Patent US9765018 (2017)

More data for this
Ligand-Target Pair