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BDBM340789 4'-(2-tert-butylphenoxy)- 4-methoxy-3'-(3-(2- (trifluoromethyl)phenyl) ureido)biphenyl-3- carboxylic acid::US9765018, Example 46

SMILES: COc1ccc(cc1C(O)=O)-c1ccc(Oc2ccccc2C(C)(C)C)c(NC(=O)Nc2ccccc2C(F)(F)F)c1

InChI Key: InChIKey=PFBKEAMDFCHFNI-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340789   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM340789
PNG
(4'-(2-tert-butylphenoxy)- 4-methoxy-3'-(3-(2- (tri...)
Show SMILES COc1ccc(cc1C(O)=O)-c1ccc(Oc2ccccc2C(C)(C)C)c(NC(=O)Nc2ccccc2C(F)(F)F)c1
Show InChI InChI=1S/C32H29F3N2O5/c1-31(2,3)23-10-6-8-12-27(23)42-28-16-14-20(19-13-15-26(41-4)21(17-19)29(38)39)18-25(28)37-30(40)36-24-11-7-5-9-22(24)32(33,34)35/h5-18H,1-4H3,(H,38,39)(H2,36,37,40)
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MMDB

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PC cid
PC sid
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US Patent
n/an/a 540n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Syngene International Limited; Bristol-Myers Squibb Company

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...


US Patent US9765018 (2017)

More data for this
Ligand-Target Pair