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BDBM340796 US9765040, Compound 7

SMILES: Cn1c(nnc1C(C)(C)Oc1c(F)cc(F)cc1F)-c1c[nH]nc1C(F)(F)F

InChI Key: InChIKey=PXFLBRNOLCGGGK-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340796   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Rattus norvegicus (rat))
BDBM340796
PNG
(US9765040, Compound 7)
Show SMILES Cn1c(nnc1C(C)(C)Oc1c(F)cc(F)cc1F)-c1c[nH]nc1C(F)(F)F
Show InChI InChI=1S/C16H13F6N5O/c1-15(2,28-11-9(18)4-7(17)5-10(11)19)14-26-25-13(27(14)3)8-6-23-24-12(8)16(20,21)22/h4-6H,1-3H3,(H,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 32n/an/an/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The procedure for measuring the 11β-HSD1-inhibitory activity is as follows. The enzyme reaction and the measurement were carried out using a 384...


US Patent US9765040 (2017)

More data for this
Ligand-Target Pair