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BDBM340821 3'-(3-(3,4- dimethylphenyl)ureido)- 4-methoxy-4'-(5,6,7,8- tetrahydronaphthalen-1- yloxy)biphenyl-3- carboxylic acid::US9765018, Example 153

SMILES: COc1ccc(cc1C(O)=O)-c1ccc(Oc2cccc3CCCCc23)c(NC(=O)Nc2ccc(C)c(C)c2)c1

InChI Key: InChIKey=QRKNBHDROOYHIO-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340821   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM340821
PNG
(3'-(3-(3,4- dimethylphenyl)ureido)- 4-methoxy-4'-(...)
Show SMILES COc1ccc(cc1C(O)=O)-c1ccc(Oc2cccc3CCCCc23)c(NC(=O)Nc2ccc(C)c(C)c2)c1
Show InChI InChI=1S/C33H32N2O5/c1-20-11-14-25(17-21(20)2)34-33(38)35-28-19-24(23-12-15-29(39-3)27(18-23)32(36)37)13-16-31(28)40-30-10-6-8-22-7-4-5-9-26(22)30/h6,8,10-19H,4-5,7,9H2,1-3H3,(H,36,37)(H2,34,35,38)
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PC cid
PC sid
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US Patent
n/an/a 920n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Syngene International Limited; Bristol-Myers Squibb Company

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...


US Patent US9765018 (2017)

More data for this
Ligand-Target Pair