BindingDB logo
myBDB logout

BDBM340899 1-isopropyl-3-(4-methyl-1H-indol-2-yl)-1H- pyrazolo[3,4-d]pyrimidin-4-amine::US9765037, Compound 25

SMILES: CC(C)n1nc(-c2cc3c(C)cccc3[nH]2)c2c(N)ncnc12

InChI Key: InChIKey=HEDDQUIXAAICJH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 340899   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM340899
PNG
(1-isopropyl-3-(4-methyl-1H-indol-2-yl)-1H- pyrazol...)
Show SMILES CC(C)n1nc(-c2cc3c(C)cccc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C17H18N6/c1-9(2)23-17-14(16(18)19-8-20-17)15(22-23)13-7-11-10(3)5-4-6-12(11)21-13/h4-9,21H,1-3H3,(H2,18,19,20)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.30n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase 1 (CDPK1)


(Toxoplasma gondii)
BDBM340899
PNG
(1-isopropyl-3-(4-methyl-1H-indol-2-yl)-1H- pyrazol...)
Show SMILES CC(C)n1nc(-c2cc3c(C)cccc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C17H18N6/c1-9(2)23-17-14(16(18)19-8-20-17)15(22-23)13-7-11-10(3)5-4-6-12(11)21-13/h4-9,21H,1-3H3,(H2,18,19,20)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.80n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair