BDBM340936 N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyrimidin-3-yl)phenyl)butyramide::US10544104, Compound 61::US11247972, Compound 61::US9765037, Compound 61

SMILES CCCC(=O)Nc1ccc(cc1)-c1nn(c2ncnc(N)c12)C(C)(C)C

InChI Key InChIKey=YRYOEVHVROHLKR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 340936   

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM340936(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
Affinity DataIC50:  68.4nMAssay Description:Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalcium-dependent protein kinase 1(Cryptosporidium parvum)
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM340936(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
Affinity DataIC50:  927nMAssay Description:Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands(Cryptosporidium parvum (strain Iowa II))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM340936(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
Affinity DataIC50:  927nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalmodulin-domain protein kinase 1, putative(Cryptosporidium parvum (strain Iowa II))
University Of Washington Through Its Center For

US Patent
LigandPNGBDBM340936(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
Affinity DataIC50:  927nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent protein kinase()
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM340936(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
Affinity DataIC50:  68.4nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM340936(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
Affinity DataIC50:  68.4nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent