BDBM341034 N-(4-Hydroxyphenyl)-N-(1H-indol-5-yl)-5-methyl-1-(6-{[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}-1,3-benzodioxol-5-yl)-1H-pyrrole-3-carboxamide::US9765056, Example 87

SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(cc2C)C(=O)N(c2ccc(O)cc2)c2ccc3[nH]ccc3c2)CC1

InChI Key InChIKey=UQKVIXUDEBFWNE-DHUJRADRSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341034   

TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM341034(N-(4-Hydroxyphenyl)-N-(1H-indol-5-yl)-5-methyl-1-(...)
Affinity DataIC50:  4.40nMAssay Description:Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent