BDBM341186 (S)-2,4-diamino-6-((cyclopropyl(6-fluoro-3-(3-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)amino)pyrimidine-5-carbonitrile ::US9765060, Compound 16a
SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3ccc(F)cc3c(=O)n2-c2cccc(F)c2)n1
InChI Key InChIKey=KRTLGTDEKUDJTP-SFHVURJKSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 341186
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 4nMAssay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...More data for this Ligand-Target Pair