BDBM341214 (S)-3-(2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(3,5-difluorophenyl)-8-fluoro-4-oxo-3,4-dihydroquinazoline-5-yl)propanamide ::US9765060, Compound 41

SMILES C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2c(F)ccc(CCC(N)=O)c2c(=O)n1-c1cc(F)cc(F)c1

InChI Key InChIKey=YQDOMQGRYFOVLB-VIFPVBQESA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341214   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM341214((S)-3-(2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)a...)
Affinity DataIC50:  25nMAssay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent