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BDBM341524 1-(5-(5-chloro-3-fluoropyridin-2-yl)-2-methyl-7,8-dihydro-[1,3,4]thiadiazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl)-2-((2-chloro-6-(3,3-difluoroazetidin-1-yl)pyridin-3-yl)oxy)ethanone::US9765092, Example 1.33.2

SMILES: Cc1nn2c3C(N(CCc3nc2s1)C(=O)COc1ccc(nc1Cl)N1CC(F)(F)C1)c1ncc(Cl)cc1F

InChI Key: InChIKey=CSYFZBNRVLSDAZ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341524   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tryptophan 5-monooxygenase 1


(Homo sapiens (Human))
BDBM341524
PNG
(1-(5-(5-chloro-3-fluoropyridin-2-yl)-2-methyl-7,8-...)
Show SMILES Cc1nn2c3C(N(CCc3nc2s1)C(=O)COc1ccc(nc1Cl)N1CC(F)(F)C1)c1ncc(Cl)cc1F
Show InChI InChI=1S/C23H18Cl2F3N7O2S/c1-11-32-35-19-14(30-22(35)38-11)4-5-34(20(19)18-13(26)6-12(24)7-29-18)17(36)8-37-15-2-3-16(31-21(15)25)33-9-23(27,28)10-33/h2-3,6-7,20H,4-5,8-10H2,1H3
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Article
US Patent
n/an/a 4n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD

US Patent


Assay Description
To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...


US Patent US9765092 (2017)


Article DOI: 10.1021/bi060173m
More data for this
Ligand-Target Pair