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BDBM341644 2-((2-chloro-6-morpholinopyridin-3-yl)oxy)-1-(5-(4-cyclopropyl-2-fluorophenyl)-7,8-dihydrothiazolo-[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl)ethanone::US9765092, Example 6.6.1

SMILES: Fc1cc(ccc1C1N(CCc2nc3sccn3c12)C(=O)COc1ccc(nc1Cl)N1CCOCC1)C1CC1

InChI Key: InChIKey=XCCFCSLAQCGUKN-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341644   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tryptophan 5-monooxygenase 1


(Homo sapiens (Human))
BDBM341644
PNG
(2-((2-chloro-6-morpholinopyridin-3-yl)oxy)-1-(5-(4...)
Show SMILES Fc1cc(ccc1C1N(CCc2nc3sccn3c12)C(=O)COc1ccc(nc1Cl)N1CCOCC1)C1CC1
Show InChI InChI=1S/C28H27ClFN5O3S/c29-27-22(5-6-23(32-27)33-9-12-37-13-10-33)38-16-24(36)34-8-7-21-26(35-11-14-39-28(35)31-21)25(34)19-4-3-18(15-20(19)30)17-1-2-17/h3-6,11,14-15,17,25H,1-2,7-10,12-13,16H2
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MMDB

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PC cid
PC sid
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Article
US Patent
n/an/a 4n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD

US Patent


Assay Description
To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...


US Patent US9765092 (2017)


Article DOI: 10.1021/bi060173m
More data for this
Ligand-Target Pair