BDBM342103 1-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-3-(4-((2-((3-(cyclopropylsulfonyl)-5-methoxy-phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9771353, Example 3

SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)n2)cc(c1)S(=O)(=O)C1CC1

InChI Key InChIKey=LUOYPPQEEBEDSR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 342103   

TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Topivert Pharma

US Patent
LigandPNGBDBM342103(1-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-3-(4-(...)
Affinity DataIC50:  1.94E+3nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3-alpha enzyme isoform (Invitrogen), are evaluated by determining the level o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 12(Homo sapiens (Human))
Topivert Pharma

US Patent
LigandPNGBDBM342103(1-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-3-(4-(...)
Affinity DataIC50:  36nMAssay Description:p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent