BDBM342439 N-(2-((4a′R,8a′R)-2′-amino-4a′,5′-dihydro-4′H-spiro[cyclobutane-1,6′-pyrano 3,4-d][1,3]oxazin]-8a′(8′H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide::US9771379, Example 14

SMILES NC1=N[C@]2(COC3(CCC3)C[C@H]2CO1)c1nc(NC(=O)c2ccc(OC(F)F)cn2)cs1

InChI Key InChIKey=SEBIYHKWQMOVBA-YBTHPKLGSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 342439   

TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM342439(N-(2-((4a′R,8a′R)-2′-amino-4a...)
Affinity DataIC50:  860nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent