BDBM342441 N-(2-((4a'R,8a'R)-2'-amino- 4a',5'-dihydro-4'H-spiro [cyclobutane-1,6'-pyrano [3,4-d][1,3]oxazin]-8a'(8'H)- yl)thiazol-4-yl)-5-cyano picolinamide::US9771379, Example 16

SMILES NC1=N[C@]2(COC3(CCC3)C[C@H]2CO1)c1nc(NC(=O)c2ccc(cn2)C#N)cs1

InChI Key InChIKey=AMDFCIZTYXEYCG-RBZFPXEDSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 342441   

TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM342441(N-(2-((4a'R,8a'R)-2'-amino- 4a',5'-dihydro-4'H-spi...)
Affinity DataIC50:  395nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent