BDBM342447 N-{2-[(4aR,6R,8aR)-2- amino-6-(trifluoromethyl)- 4,4a,5,6-tetrahydropyrano [3,4-d][1,3]oxazin-8a(8H)-yl]- 1,3-thiazol-4-yl}-5- (difluoromethoxy)-3-methyl pyrazine-2-carboxamide::US9771379, Example 22

SMILES Cc1nc(OC(F)F)cnc1C(=O)Nc1csc(n1)[C@]12CO[C@H](C[C@H]1COC(N)=N2)C(F)(F)F

InChI Key InChIKey=KZSWBENUZHVEIJ-BTKFHORUSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 342447   

TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM342447(N-{2-[(4aR,6R,8aR)-2- amino-6-(trifluoromethyl)- 4...)
Affinity DataIC50:  13nMAssay Description:The BACE1 binding assay measured beta-site amyloid precursor protein-cleaving enzyme (BACE) binding as a decrease in the counts of radioligand bound ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent