BDBM343647 N1-(6-Benzyl-1,7-dimethyl-6H- pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyridin- 4-yl)-N2,N2-dimethylethane-1,2-diamine::US10442803, Example 246::US11091484, Example 246::US9777003, Example 246

SMILES CN(C)CCNc1cc2n(Cc3ccccc3)c(C)cc2n2c(C)nnc12

InChI Key InChIKey=PICPTBJDRVLBAL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 343647   

TargetBromodomain-containing protein 4 [42-168](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM343647(N1-(6-Benzyl-1,7-dimethyl-6H- pyrrolo[2,3-e][1,2,4...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [342-460](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM343647(N1-(6-Benzyl-1,7-dimethyl-6H- pyrrolo[2,3-e][1,2,4...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [368-440](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM343647(N1-(6-Benzyl-1,7-dimethyl-6H- pyrrolo[2,3-e][1,2,4...)
Affinity DataIC50: <100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [342-460](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM343647(N1-(6-Benzyl-1,7-dimethyl-6H- pyrrolo[2,3-e][1,2,4...)
Affinity DataIC50: <1.00E+3nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM343647(N1-(6-Benzyl-1,7-dimethyl-6H- pyrrolo[2,3-e][1,2,4...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [42-168](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM343647(N1-(6-Benzyl-1,7-dimethyl-6H- pyrrolo[2,3-e][1,2,4...)
Affinity DataIC50: <1.00E+3nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent