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BDBM343874 US9777008, Compound 168

SMILES: COc1ccc(cc1Cl)-c1cccc(OCC(O)CN2CCc3ccccc3C2)c1

InChI Key: InChIKey=RDAZZHZFRAMBDO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 343874   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343874
PNG
(US9777008, Compound 168)
Show SMILES COc1ccc(cc1Cl)-c1cccc(OCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C25H26ClNO3/c1-29-25-10-9-20(14-24(25)26)19-7-4-8-23(13-19)30-17-22(28)16-27-12-11-18-5-2-3-6-21(18)15-27/h2-10,13-14,22,28H,11-12,15-17H2,1H3
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair