BindingDB logo
myBDB logout

BDBM343952 US9777008, Compound 246

SMILES: OC(CNc1cc(ccn1)-c1ncc2ccn(CC(=O)N3CCCCC3)c2n1)CN1CCc2ccccc2C1

InChI Key: InChIKey=BWOFZDRTMFRKJS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 343952   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343952
PNG
(US9777008, Compound 246)
Show SMILES OC(CNc1cc(ccn1)-c1ncc2ccn(CC(=O)N3CCCCC3)c2n1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C30H35N7O2/c38-26(20-35-14-9-22-6-2-3-7-25(22)19-35)18-32-27-16-23(8-11-31-27)29-33-17-24-10-15-37(30(24)34-29)21-28(39)36-12-4-1-5-13-36/h2-3,6-8,10-11,15-17,26,38H,1,4-5,9,12-14,18-21H2,(H,31,32)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair