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BDBM343967 US9777008, Compound 261

SMILES: Cn1cc2ccc(nc2n1)-c1cccc(NCC(O)CN2CCc3ccccc3C2)c1

InChI Key: InChIKey=DUIRHBALGBUWCU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 343967   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343967
PNG
(US9777008, Compound 261)
Show SMILES Cn1cc2ccc(nc2n1)-c1cccc(NCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C25H27N5O/c1-29-15-21-9-10-24(27-25(21)28-29)19-7-4-8-22(13-19)26-14-23(31)17-30-12-11-18-5-2-3-6-20(18)16-30/h2-10,13,15,23,26,31H,11-12,14,16-17H2,1H3
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair