BDBM344030 US10370387, Example 14::US11161855, Example 14::US9777017, Example 14::US9908895, Example 14

SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)n1c(nc2cnc3ccsc3c12)[C@@H](C)O

InChI Key InChIKey=DBYVHOSSLNCWHZ-JHJVBQTASA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 344030   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM344030(US10370387, Example 14 | US11161855, Example 14 | ...)
Affinity DataIC50: <1.00E+3nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM344030(US10370387, Example 14 | US11161855, Example 14 | ...)
Affinity DataIC50: >2.00E+4nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM344030(US10370387, Example 14 | US11161855, Example 14 | ...)
Affinity DataIC50: <1.00E+3nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM344030(US10370387, Example 14 | US11161855, Example 14 | ...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1 [837-1142](Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM344030(US10370387, Example 14 | US11161855, Example 14 | ...)
Affinity DataIC50: <1.00E+3nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM344030(US10370387, Example 14 | US11161855, Example 14 | ...)
Affinity DataIC50: >5.00E+5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1 [837-1142](Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM344030(US10370387, Example 14 | US11161855, Example 14 | ...)
Affinity DataIC50: <1.00E+3nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM344030(US10370387, Example 14 | US11161855, Example 14 | ...)
Affinity DataIC50: >5.00E+3nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent