BDBM344372 US10251889, Example 81::US10758542, Example 81::US9782415, Example 81::US9796724, Example 81

SMILES CC(C)(CF)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)cnc1CO

InChI Key InChIKey=XHJBITNPWPZMGB-QGZVFWFLSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 344372   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM344372(US10251889, Example 81 | US10758542, Example 81 | ...)
Affinity DataIC50:  1.15nMAssay Description:An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM344372(US10251889, Example 81 | US10758542, Example 81 | ...)
Affinity DataIC50:  666nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM344372(US10251889, Example 81 | US10758542, Example 81 | ...)
Affinity DataIC50:  1.15nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM344372(US10251889, Example 81 | US10758542, Example 81 | ...)
Affinity DataIC50:  666nMAssay Description:Jak2: Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM344372(US10251889, Example 81 | US10758542, Example 81 | ...)
Affinity DataIC50:  1.15nMAssay Description:Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM344372(US10251889, Example 81 | US10758542, Example 81 | ...)
Affinity DataIC50:  666nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM344372(US10251889, Example 81 | US10758542, Example 81 | ...)
Affinity DataIC50:  1.15nMAssay Description:An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM344372(US10251889, Example 81 | US10758542, Example 81 | ...)
Affinity DataIC50:  666nMAssay Description:An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent