BDBM344706 1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(4-methyl-2-oxopentyl)imidazolidin-2-one::US9783527, Example 8

SMILES CC(C)CC(=O)CN1CCN(C1=O)c1cccc2n(ncc12)-c1ccccc1F

InChI Key InChIKey=XTPMCCMBFJVEOA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 344706   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM344706(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(4-methyl...)
Affinity DataIC50:  491nMAssay Description:Two days prior to the experiment, frozen HEK293 cells stably expressing recombinant human Nav1.7 were quickly thawed and plated at 25,000 cells/well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM344706(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(4-methyl...)
Affinity DataIC50:  666nMAssay Description:Two days prior to the experiment, frozen HEK293 cells stably expressing recombinant human Nav1.8 (Essen, Ann Arbor, Mich.) were quickly thawed and pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM344706(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(4-methyl...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293F cells measured at -65 mV holding potential by Qpatch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM344706(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(4-methyl...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by whole cell-patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM344706(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(4-methyl...)
Affinity DataIC50:  570nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed