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BDBM345470 Butane-1-sulfonic acid [2-(2-chloro- 5-methyl-phenoxy)-6-(1,5-dimethyl- 6-oxo-1,6-dihydro-pyridin-3-yl)- pyrimidin-4-yl]-amide::US10202360, Example 15

SMILES: CCCCS(=O)(=O)Nc1cc(nc(Oc2cc(C)ccc2Cl)n1)-c1cc(C)c(=O)n(C)c1

InChI Key: InChIKey=RXXJBTOZCNCGIK-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 345470   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein


(Homo sapiens (Human))
BDBM345470
PNG
(Butane-1-sulfonic acid [2-(2-chloro- 5-methyl-phen...)
Show SMILES CCCCS(=O)(=O)Nc1cc(nc(Oc2cc(C)ccc2Cl)n1)-c1cc(C)c(=O)n(C)c1
Show InChI InChI=1S/C22H25ClN4O4S/c1-5-6-9-32(29,30)26-20-12-18(16-11-15(3)21(28)27(4)13-16)24-22(25-20)31-19-10-14(2)7-8-17(19)23/h7-8,10-13H,5-6,9H2,1-4H3,(H,24,25,26)
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MMDB

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US Patent
n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
Determination of the IC50 for the CREBBP inhibitors disclosed herein was performed as follows: CREBBP was cloned and expressed in E. Coli as His-tag ...


US Patent US10202360 (2019)

More data for this
Ligand-Target Pair