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BDBM345479 Propane-2-sulfonic acid [2-(2- cyano-6-methyl-phenoxy)-6-(1,5- dimethyl-6-oxo-1,6-dihydro-pyridin- 3-yl)-pyrimidin-4-yl]-amide::US10202360, Example 24

SMILES: CC(C)S(=O)(=O)Nc1cc(nc(Oc2c(C)cccc2C#N)n1)-c1cc(C)c(=O)n(C)c1

InChI Key: InChIKey=WJPGWIVQLNUAHL-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 345479   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein


(Homo sapiens (Human))
BDBM345479
PNG
(Propane-2-sulfonic acid [2-(2- cyano-6-methyl-phen...)
Show SMILES CC(C)S(=O)(=O)Nc1cc(nc(Oc2c(C)cccc2C#N)n1)-c1cc(C)c(=O)n(C)c1
Show InChI InChI=1S/C22H23N5O4S/c1-13(2)32(29,30)26-19-10-18(17-9-15(4)21(28)27(5)12-17)24-22(25-19)31-20-14(3)7-6-8-16(20)11-23/h6-10,12-13H,1-5H3,(H,24,25,26)
PDB
MMDB

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US Patent
n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
Determination of the IC50 for the CREBBP inhibitors disclosed herein was performed as follows: CREBBP was cloned and expressed in E. Coli as His-tag ...


US Patent US10202360 (2019)

More data for this
Ligand-Target Pair