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BDBM345516 N-(2-(2,4-difluorophenoxy)-6-(1,5- dimethyl-6-oxo-1,6-dihydropyridin- 3-yl)pyrimidin-4- yl)methanesulfonamide::US10202360, Example 61

SMILES: Cc1cc(cn(C)c1=O)-c1cc(NS(C)(=O)=O)nc(Oc2ccc(F)cc2F)n1

InChI Key: InChIKey=HWXLIQFUOORIJZ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 345516   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein


(Homo sapiens (Human))
BDBM345516
PNG
(N-(2-(2,4-difluorophenoxy)-6-(1,5- dimethyl-6-oxo-...)
Show SMILES Cc1cc(cn(C)c1=O)-c1cc(NS(C)(=O)=O)nc(Oc2ccc(F)cc2F)n1
Show InChI InChI=1S/C18H16F2N4O4S/c1-10-6-11(9-24(2)17(10)25)14-8-16(23-29(3,26)27)22-18(21-14)28-15-5-4-12(19)7-13(15)20/h4-9H,1-3H3,(H,21,22,23)
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
Determination of the IC50 for the CREBBP inhibitors disclosed herein was performed as follows: CREBBP was cloned and expressed in E. Coli as His-tag ...


US Patent US10202360 (2019)

More data for this
Ligand-Target Pair