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BDBM345560 N-(2-(2,6-dimethylphenoxy)-6-(5- methoxy-1-methyl-6-oxo-1,6- dihydropyridin-3-yl)pyrimidin-4- yl)propane-2-sulfonamide::US10202360, Example 105

SMILES: COc1cc(cn(C)c1=O)-c1cc(NS(=O)(=O)C(C)C)nc(Oc2c(C)cccc2C)n1

InChI Key: InChIKey=VXNKMLMVNMEAAE-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 345560   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein


(Homo sapiens (Human))
BDBM345560
PNG
(N-(2-(2,6-dimethylphenoxy)-6-(5- methoxy-1-methyl-...)
Show SMILES COc1cc(cn(C)c1=O)-c1cc(NS(=O)(=O)C(C)C)nc(Oc2c(C)cccc2C)n1
Show InChI InChI=1S/C22H26N4O5S/c1-13(2)32(28,29)25-19-11-17(16-10-18(30-6)21(27)26(5)12-16)23-22(24-19)31-20-14(3)8-7-9-15(20)4/h7-13H,1-6H3,(H,23,24,25)
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
Determination of the IC50 for the CREBBP inhibitors disclosed herein was performed as follows: CREBBP was cloned and expressed in E. Coli as His-tag ...


US Patent US10202360 (2019)

More data for this
Ligand-Target Pair