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BDBM345561 N-(2-(2,6-dimethylphenoxy)-6-(5- methoxy-1-methyl-6-oxo-1,6- dihydropyridin-3-yl)pyrimidin-4- yl)butane-1-sulfonamide::US10202360, Example 106

SMILES: CCCCS(=O)(=O)Nc1cc(nc(Oc2c(C)cccc2C)n1)-c1cc(OC)c(=O)n(C)c1

InChI Key: InChIKey=NOKVKCLTTUPAGC-UHFFFAOYSA-N

Data: 1 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 345561   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein


(Homo sapiens (Human))
BDBM345561
PNG
(N-(2-(2,6-dimethylphenoxy)-6-(5- methoxy-1-methyl-...)
Show SMILES CCCCS(=O)(=O)Nc1cc(nc(Oc2c(C)cccc2C)n1)-c1cc(OC)c(=O)n(C)c1
Show InChI InChI=1S/C23H28N4O5S/c1-6-7-11-33(29,30)26-20-13-18(17-12-19(31-5)22(28)27(4)14-17)24-23(25-20)32-21-15(2)9-8-10-16(21)3/h8-10,12-14H,6-7,11H2,1-5H3,(H,24,25,26)
PDB
MMDB

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US Patent
n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
Determination of the IC50 for the CREBBP inhibitors disclosed herein was performed as follows: CREBBP was cloned and expressed in E. Coli as His-tag ...


US Patent US10202360 (2019)

More data for this
Ligand-Target Pair