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BDBM345580 Propane-2-sulfonic acid [6-(1- methyl-6-oxo-1,6-dihydro-pyridin- 3-yl)-2-(1,3,5-trimethyl-1H-pyrazol- 4-yloxy)-pyrimidin-4-yl]-amide::US10202360, Example 125

SMILES: CC(C)S(=O)(=O)Nc1cc(nc(Oc2c(C)nn(C)c2C)n1)-c1ccc(=O)n(C)c1

InChI Key: InChIKey=OCEGJKYOSMSHNC-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 345580   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein


(Homo sapiens (Human))
BDBM345580
PNG
(Propane-2-sulfonic acid [6-(1- methyl-6-oxo-1,6-di...)
Show SMILES CC(C)S(=O)(=O)Nc1cc(nc(Oc2c(C)nn(C)c2C)n1)-c1ccc(=O)n(C)c1
Show InChI InChI=1S/C19H24N6O4S/c1-11(2)30(27,28)23-16-9-15(14-7-8-17(26)24(5)10-14)20-19(21-16)29-18-12(3)22-25(6)13(18)4/h7-11H,1-6H3,(H,20,21,23)
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
Determination of the IC50 for the CREBBP inhibitors disclosed herein was performed as follows: CREBBP was cloned and expressed in E. Coli as His-tag ...


US Patent US10202360 (2019)

More data for this
Ligand-Target Pair