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BDBM345588 5-[2-(2-Chloro-6-methyl-phenoxy)- 6-methanesulfonyl-pyrimidin-4-yl]- 1,3-dimethyl-1H-pyridin-2-one::US10202360, Example 133

SMILES: Cc1cccc(C#N)c1Oc1nc(cc(n1)S(C)(=O)=O)-c1cc(C)c(=O)n(C)c1

InChI Key: InChIKey=OJHRNTFYJMBKFW-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 345588   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein


(Homo sapiens (Human))
BDBM345588
PNG
(5-[2-(2-Chloro-6-methyl-phenoxy)- 6-methanesulfony...)
Show SMILES Cc1cccc(C#N)c1Oc1nc(cc(n1)S(C)(=O)=O)-c1cc(C)c(=O)n(C)c1
Show InChI InChI=1S/C20H18N4O4S/c1-12-6-5-7-14(10-21)18(12)28-20-22-16(9-17(23-20)29(4,26)27)15-8-13(2)19(25)24(3)11-15/h5-9,11H,1-4H3
PDB
MMDB

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KEGG

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PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
Determination of the IC50 for the CREBBP inhibitors disclosed herein was performed as follows: CREBBP was cloned and expressed in E. Coli as His-tag ...


US Patent US10202360 (2019)

More data for this
Ligand-Target Pair