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BDBM345637 Butane-1-sulfonic acid [4-(2-chloro- 6-fluoro-phenoxy)-6-(1-methyl-6- oxo-1,6-dihydro-pyridin-3-yl)- [1,3,5]triazin-2-yl]-amide::US10202360, Example 182

SMILES: CCCCS(=O)(=O)Nc1nc(Oc2c(F)cccc2Cl)nc(n1)-c1ccc(=O)n(C)c1

InChI Key: InChIKey=ZPCXBYYNNQOPPR-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 345637   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein


(Homo sapiens (Human))
BDBM345637
PNG
(Butane-1-sulfonic acid [4-(2-chloro- 6-fluoro-phen...)
Show SMILES CCCCS(=O)(=O)Nc1nc(Oc2c(F)cccc2Cl)nc(n1)-c1ccc(=O)n(C)c1
Show InChI InChI=1S/C19H19ClFN5O4S/c1-3-4-10-31(28,29)25-18-22-17(12-8-9-15(27)26(2)11-12)23-19(24-18)30-16-13(20)6-5-7-14(16)21/h5-9,11H,3-4,10H2,1-2H3,(H,22,23,24,25)
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US Patent
n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
Determination of the IC50 for the CREBBP inhibitors disclosed herein was performed as follows: CREBBP was cloned and expressed in E. Coli as His-tag ...


US Patent US10202360 (2019)

More data for this
Ligand-Target Pair