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BDBM345677 (S)-N-(2-(2-chloro-6- methylphenoxy)-6-(1,5-dimethyl-6- oxo-1,6-dihydropyridin-3- yl)pyrimidin-4-yl)butane-2- sulfonamide::US10202360, Example 222

SMILES: CC[C@H](C)S(=O)(=O)Nc1cc(nc(Oc2c(C)cccc2Cl)n1)-c1cc(C)c(=O)n(C)c1

InChI Key: InChIKey=VZMIXXLNRSQGKE-HNNXBMFYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 345677   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein


(Homo sapiens (Human))
BDBM345677
PNG
((S)-N-(2-(2-chloro-6- methylphenoxy)-6-(1,5-dimeth...)
Show SMILES CC[C@H](C)S(=O)(=O)Nc1cc(nc(Oc2c(C)cccc2Cl)n1)-c1cc(C)c(=O)n(C)c1
Show InChI InChI=1S/C22H25ClN4O4S/c1-6-15(4)32(29,30)26-19-11-18(16-10-14(3)21(28)27(5)12-16)24-22(25-19)31-20-13(2)8-7-9-17(20)23/h7-12,15H,6H2,1-5H3,(H,24,25,26)/t15-/m0/s1
PDB
MMDB

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US Patent
n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
Determination of the IC50 for the CREBBP inhibitors disclosed herein was performed as follows: CREBBP was cloned and expressed in E. Coli as His-tag ...


US Patent US10202360 (2019)

More data for this
Ligand-Target Pair